Structure elucidation of natural products and bioactive compounds

For selected publications see:

Prenylated isoflavones from the stem bark of Erythrina sacleuxii
J. O. Ombito, R. R.T. Majinda, I. B. Masesane, G. Bojase, A. Schüffler, Till Opatz, Phytochem Lett. 2018, 26, 110–114.

Phytotoxic dioxolanones are potential virulence factors in the infection process of Guignardia bidwellii
I. Buckel, L. Andernach, A. Schüffler, M. Piepenbring, T. Opatz, E. Thines, Sci. Rep. 2017, 7, 8926.

A New Member of the Fusaricidin Family – Structure Elucidation and Synthesis of Fusaricidin E
M. Reimann, L. P. Sandjo, L Antelo, E. Thines, I. Siepe, T. Opatz, Beilstein J. Org. Chem. 2017, 13, 1430–1438.

Cytotoxicity of Secondary Metabolites from Dracaena viridiflora Engl & Krause and their Semisynthetic Analogues
R. B. Teponno, J. P. Dzoyem, R. N. Nono, U. Kauhl, L. P. Sandjo, L. A. Tapondjou, U. Bakowsky, T. Opatz, Rec. Nat. Prod. 2017, 11, 421–430.

The Chinese herbal formula Free and Easy Wanderer ameliorates oxidative stress through the KEAP1-NRF2/HO-1 pathway
C. Hong, J. Cao, C.-F. Wu, O. Kadioglu, A. Schüffler, U. Kauhl, S. M. Klauck, T. Opatz, E. Thines, T. Efferth, Sci. Rep. 2017, 7, 11551.

Identification of NF-κB as Determinant of Posttraumatic Stress Disorder and Its Inhibiton by the Chinese Herbal Remedy Free and Easy Wanderer
C. Hong, A. Schüffler, U. Kauhl, J. Cao, C.-F. Wu, T. Opatz, E. Thines, T. Efferth, Front. Pharmacol. 2017, 8, 181.

ESI-MS2 and anti-inflammatory studies of cyclopropanic triterpenes. UPLC-ESI-MS and MS2 search of related metabolites from Donella ubanguiensis
L. P. Sandjo, M. V. P. dos Santos Nascimento, L. A. L. da Silva, A. C. M. Munhoz, L. A. E. Pollo, M. W. Biavatti, B. T. Ngadjui, T. Opatz, T. S. Fröde
Phytochem. Anal. 2017, 28, 27–41.

Unravelling the biosynthesis of pyriculol in the rice blast fungus Magnaporthe oryzae
Stefan Jacob; Thomas Grötsch; Andrew J. Foster; Anja Schüffler; Patrick H. Rieger; Louis P. Sandjo; Johannes C. Liermann; Till Opatz; Eckhard Thines
Microbiology 2017, 163, 541–553.

Characterization of the synthetic cannabinoid MDMB-CHMCZCA
Carina Weber, Stefan Pusch, Dieter Schollmeyer, Sascha Münster-Müller, Michael Pütz and Till Opatz
Beilstein J. Org. Chem. 2016, 12, 2808–2815.

Anti-inflammatory Tetraquinane Diterpenoids from a Crinipellis species
Markus Rohr, Katharina Oleinikov, Mathias Jung, Louis P. Sandjo, Till Opatz, Gerhard Erkel
Bioorg. Med. Chem. 2016, 25, 514–522.

Absolute Configuration Determination of 2,3-Dihydro-1H,5H-pyrazolo-[1,2-a]pyrazoles using Chiroptical Methods at Different Wavelengths.
Eva Pušavec Kirar, Uroš Grošelj, Amalija Golobič, Franc Požgan, Stefan Pusch, Carina Weber, Lars Andernach, Bogdan Štefane, Till Opatz, Jurij Svete
J. Org. Chem. 2016, 81, 11802–11812.

Terphenyl Derivatives from Allantophomopsis lycopodina
Andernach, Lars; Sandjo, Louis; Liermann, Johannes; Schlämann, Ricardo; Richter, Christian; Ferner, Jan-Peter; Schwalbe, Harald; Schueffler, Anja; Thines, Eckhard; Opatz, Till
J. Nat. Prod. 2016, 79, 2718–2725.

Separation, isolation and stereochemical assignment of imazalil enantiomers and their quantitation in an in vitro toxicity test
M. Escolà Casas, A. C. Kretschmann, L. Andernach, T. Opatz, K. Bester
J. Chromatogr. A 2016, 1452, 116-120.

Absolute configuration of the synthetic cannabinoid MDMB-CHMICA with its chemical characteristics in illegal products
L. Andernach, S. Pusch, C. Weber, D. Schollmeyer, S. Münster-Müller, M. Pütz, T. Opatz, Forensic Toxicol. 2016, 34, 344-352.

A Surprising Switch in Absolute Configuration of Anti-Inflammatory Macrolactones
J. Tauber, M. Rohr, T. Walter, D. Schollmeyer, K. Rahn-Hotze, G. Erkel, T. Opatz
Org. Biomol. Chem. 2016, 14, 3695-3698.

Marine Isonitriles and Their Related Compounds
J. Emsermann, U. Kauhl, T. Opatz
Marine Drugs 2016, 14, 16.