Dr. Philipp Klein


Institute of Organic Chemistry
Johannes Gutenberg-University Mainz
Duesbergweg 10-14, 55128 Mainz
Room 2.223/01-124
Phone (06131) 39-22364
E-mail pklein01[at]students.uni-mainz.de
Research interests: Organic synthesis, protease inhibitors, N-heterocyclic compounds, tools for proteomics, organic dyes, liquid crystals

Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure–Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies

S. Jung, N. Fuchs, P. Johe, A. Wagner, E. Diehl, T. Yuliani, C. Zimmer, F. Barthels, R. Zimmermann, P. Klein, W. Waigel, J. Meyr, T. Opatz, S. Tenzer, U. Distler, H. J. Räder, C. Kersten, B. Engels, U. Hellmich,  J. Klein, T. Schirmeister, J. Med. Chem. 2021, 64, 12322-12358.

Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases – Studies on Inhibition Mechanism and Kinetics
P. Klein, F. Barthels, P. Johe, A. Wagner, S. Tenzer, U. Distler, T. A. Le, P. Schmid, V. Engel, B. Engels, U. A. Hellmich, T. Opatz, T. Schirmeister, Molecules, 2020, 25, 2064.

Predicting 19 F NMR chemical shifts: A combined computational and experimental study of a trypasonomal oxidoreductase-inhibitor complex
J. C. B. Dietschreit, A. Wagner, T. Anh Le, P. Klein, H. Schindelin, T. Opatz, B. Engels, U. A. Hellmich, C. Ochsenfeld, Angew. Chem. Int. Ed. 2020, 59, 12669–12673.

New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and unexpected Prodrug Identification
P. Klein, P. Johé, A. Wagner, S. Jung, B. Engels, J. Kühlborn, S. Tenzer, U. Distler, W. Waigel, U. A. Hellmich, T. Opatz, T. Schirmeister, Molecules, 2020, 25, 1451.

Halogenated 2,1,3-benzoxadiazoles as Potential Fluorescent Warheads for Covalent Protease Inhibitors
A. Kuznetsova, P. Klein, T. Opatz, Proceedings 2019, 9, 54.

Inhibitor-induced dimerization of an essential oxidoreductase from African Trypanosomes
A. Wagner, T. A. Le, M. Brennich, P. Klein, N. Bader, E. Diehl, D. Paszek, A. K. Weickhmann, N. Dirdjaja, R. L. Krauth-Siegel, B. Engels, T. Opatz, H. Schindelin, U. A. Hellmich, Angew. Chem. 2019, 1313679-3683.

Donor–Acceptor Polymers for Electrochemical Supercapacitors: Synthesis, Testing, and Theory
P. M. DiCarmine, T. B. Schon, T. M. McCormick, P. P. Klein, D. S. Seferos, J. Phys. Chem. C 2014, 118, 8295–8307.