Dr. Matthias Krumb


Institute of Organic Chemistry
Johannes Gutenberg-University Mainz
Duesbergweg 10-14, 55128 Mainz
Room 2.223/02-131
Phone (06131) 39-25356
E-mail krumb[at]uni-mainz.de
Research interests: Carbohydrate chemistry, total synthesis, photoredox catalysis

One-pot Synthesis of CRBN PROTACs via Photoinduced C(sp2)C(sp3) Cross Coupling and Amide Formation for PROTAC Library Synthesis.

C. M. Arndt, J. Bitai, J. Brunner, T. Opatz, P. Martinelli, A. Gollner, K. R. Sokol, M. Krumb, J. Med. Chem., 2023, accepted.

Sesquiterpene Lactones from Vernonia tufnelliae: Structural Features, Stereochemistry, and Biological Evaluation

G. Bitchagno, A. Schueffler, J. Groß, M. Krumb, P. Tané, T. Opatz, J. Nat. Prod., 2022, 85, 1681-1690.

Multivalency beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells
M. Krumb, M. L. Frey, J. Langhanki, R. Forster, D. Kowalczyk, V. Mailänder, K. Landfester, T. Opatz, Cells, 2020, 2087.
This article is a contribution within the CRC1066 and appears in the special issue: Nanoparticles in Cancer Immunotherapy

Total Synthesis of a Partial Structure from Arabinogalactan and its Application for Allergy-Prevention
M. Krumb, M. Jäger, A. Voss, L. Immig, K. Peters, D. Kowalczyk, A. Bufe, T. Opatz, O. Holst, C. Vogel, M. Peters, Chem. Eur. J., 2021, 27, 928.

This article was selected as "Hot Paper" and as Cover Picture of Chemistry - A European Journal.

Photoredox-Catalyzed Four Component Reaction for the Synthesis of Complex Secondary Amines

L. M. Kammer, M. Krumb, B. Spitzbarth, B. Lipp, J. Kühlborn, J. Busold, O. M. Mulina, A. O. Terentev and T. Opatz, Org. Lett. 2020, 22, 3318−3322. (Back Cover)

Targeting of Immune Cells with Trimannosylated Liposomes

K. Wagener, M. Bros, M. Krumb, J. Langhanki, S. Pektor, M. Worm, M. Schinnerer, E. Montermann, M. Miederer, H. Frey, T. Opatz, F. Rösch, Adv. Therap.2020, 1900185

Visible Light-Induced Cleavage of C–S bonds in Thioacetals and Thioketals with Iodine as a Photocatalyst
M. Krumb, L. M. Kammer, R. Forster, C. Grundke, T. Opatz, ChemPhotoChem. 20204, 101 – 104.
This article was selected as Very Important Paper and also appears in: Hot Topic: Photocatalysis and Special collection: Photochemical Synthesis. (Cover Picture)

Neo-clerodane diterpenoids from Conyza pyrrhopappa Sch.Bip. ex A.Rich
G. T. M. Bitchagno, A. Schüffler, M. Krumb, P. Tane, T. Opatz, Nat. Prod. Res. 2019, DOI: 10.1080/14786419.2019.1690490.

HPMA-Based Nanocarriers for Effective Immune System Stimulation
S. Kramer, J. Langhanki, M. Krumb, T. Opatz, M. Bros, R. Zentel, Macromol. Biosci. 2019, 1800481.

Visible Light Enables Aerobic Iodine Catalyzed Glycosylation
M. Krumb, T. Lucas, T. Opatz, Eur. J. Org. Chem. 2019, 4517-4521.
Front Cover of Issue 28.

Bioconjugation of small molecules to RNA impedes its recognition by Toll-like receptor 7 (TLR7)
I. Hellmuth, I. Freund, J. Schlöder, S. Seidu-Larry, K. Thüring, K. Slama, J. Langhanki, S. Kaloyanova, T. Eigenbrod, M. Krumb, S. Röhm, K. Peneva, T. Opatz, H. Jonuleit, A. H. Dalpke, M. Helm, Front. Immunol. 2017, 8, 312.