M. Sc. Tobias Lucas

Institute of Organic Chemistry
Johannes Gutenberg-University Mainz
Duesbergweg 10-14, 55128 Mainz
Room 2.223/02-124
Phone (06131) 39-22288
E-Mail tolucas[at]uni-mainz.de

Research interests:

Total synthesis, HIV enzyme inhibitors, Active pharmaceutical ingredients, Heterocycles, Flow Chemistry

Publications:

Six-Step Gram Scale Synthesis of the HIV Integrase Inhibitor Dolutegravir Sodium

J.-P. Dietz, T. Lucas, J. Groß, S. Seitel, J. Brauer, D. Ferenc, B. F. Gupton, T. Opatz, Org. Process Res. Dev. 2021, accepted manuscript.

A Concise Route to MK-4482 (EIDD-2801) from Cytidine
N. Vasudevan, G. Ahlqvist, C. P. McGeough, D. J. Paymode, F. S. P. Cardoso, T. Lucas, J.-P. Dietz, T. Opatz, T. F. Jamison, B. F. Gupton,D. R. Snead, Chem. Commun., 2020, 56, 13363-13364.

Glucose as an eco‐friendly reductant in a one‐pot synthesis of 2,3‐dihydroquinazolin‐4(1H)‐ones
T. dos Santos, C.Grundke, T. Lucas, L. Großmann, G. C. Closoki, T. Opatz, Eur. J. Org. Chem., 2020, 6429-6432.

Total synthesis and biological evaluation of seven new anti-inflammatory oxacyclododecindione-type macrolactones
C. Weber, N. Vierengel, T. Walter, T. Behrendt, T. Lucas, G. Erkel and T. Opatz, Org. Biomol. Chem., 2020, 18, 5906-5917.

Synthesis of 4-Amino-5-fluoropyrimidines and 5-Amino-4-fluoropyrazoles from a β-Fluoroenolate Salt
T. Lucas, J.-P. Dietz, T. Opatz, Beilstein J. Org. Chem. 2020, 16, 445–450.

Visible Light Enables Aerobic Iodine Catalyzed Glycosylation
M. Krumb, T. Lucas, T. Opatz, Eur. J. Org. Chem. 2019, 4517-4521.
Front Cover of Issue 28.