Dr. Tobias Lucas

 

Department of Chemistry
Johannes Gutenberg-University Mainz
Duesbergweg 10-14, 55128 Mainz
Room 2.223/02-124
Phone (06131) 39-22288
E-Mail tolucas[at]uni-mainz.de
Research interests: Total synthesis, HIV enzyme inhibitors, Active pharmaceutical ingredients, Heterocycles, Flow Chemistry
Publications:

A Short and Efficient Synthesis of the Anti-Tuberculosis Agent Pretomanid from (R)-Glycidol

T. Lucas, J.-P. Dietz, F. Cardoso, D. Snead, R. Nelson, K. Donsbach, F. B. Gupton, T. Opatz, Org. Process Res. Dev., 2023, 27(9), 1641-1651.

Pharmacology, prevalence in Germany, and analytical data of cyclobutylmethyl- and norbornylmethyl-type synthetic cannabinoid receptor agonists

B. Pulver, J. Riedel, T. Schönberger, S. Halter, T. Lucas, T. Opatz, K. E. Grafinger, M. Scheu, A. Zschiesche, M. Pütz, K. Putzer, F. Westphal, V. Auwärter, Drug Test Anal., 2023, 1-8.

Diastereoselectivity is in the Details: Minor Changes Yield Major Improvements to the Synthesis of Bedaquiline

S. J. Mear, T. Lucas, G. P. Ahlqvist, J. M. S. Robey, J.-P. Dietz, P. V. Khairnar, S. Maity, C. L. Williams, D. R. Snead, R. C. Nelson, T. Opatz, T. F. Jamison, Chem. Eur. J., 2022, 28, e202201311.

Structure elucidation of the novel synthetic cannabinoid Cumyl-tosyl-indazole-3-carboxamide (Cumyl-TsINACA) found in illicit products in Germany

B. Pulver, T. Schönberger, D. Weigel, M. Köck, Y. Eschenlohr, T. Lucas, N. Podlesnik, T. Opatz, W. Dreiseitel, M. Pütz, J. Schäper, V. Auwärter, F. Westphal, Drug Test. Anal., 2022, 1–20.

Six-Step Gram Scale Synthesis of the HIV Integrase Inhibitor Dolutegravir Sodium

J.-P. Dietz, T. Lucas, J. Groß, S. Seitel, J. Brauer, D. Ferenc, B. F. Gupton, T. Opatz, Org. Process Res. Dev. 2021, 25, 1898–1910.

A Concise Route to MK-4482 (EIDD-2801) from Cytidine
N. Vasudevan, G. Ahlqvist, C. P. McGeough, D. J. Paymode, F. S. P. Cardoso, T. Lucas, J.-P. Dietz, T. Opatz, T. F. Jamison, B. F. Gupton,D. R. Snead, Chem. Commun., 2020, 56, 13363-13364.

Glucose as an eco‐friendly reductant in a one‐pot synthesis of 2,3‐dihydroquinazolin‐4(1H)‐ones
T. dos Santos, C.Grundke, T. Lucas, L. Großmann, G. C. Clososki, T. Opatz, Eur. J. Org. Chem., 2020, 6429-6432.

Total synthesis and biological evaluation of seven new anti-inflammatory oxacyclododecindione-type macrolactones
C. Weber, N. Vierengel, T. Walter, T. Behrendt, T. Lucas, G. Erkel and T. Opatz, Org. Biomol. Chem., 2020, 18, 5906-5917.

Synthesis of 4-Amino-5-fluoropyrimidines and 5-Amino-4-fluoropyrazoles from a β-Fluoroenolate Salt
T. Lucas, J.-P. Dietz, T. Opatz, Beilstein J. Org. Chem. 2020, 16, 445–450.

Visible Light Enables Aerobic Iodine Catalyzed Glycosylation
M. Krumb, T. Lucas, T. Opatz, Eur. J. Org. Chem. 2019, 4517-4521.
Front Cover of Issue 28.