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Department of Chemistry Johannes Gutenberg-University Mainz Duesbergweg 10-14, 55128 Mainz Room 2.223/02-124 Phone (06131) 39-22288 E-Mail tolucas[at]uni-mainz.de |
| Research interests: | Total synthesis, HIV enzyme inhibitors, Active pharmaceutical ingredients, Heterocycles, Flow Chemistry |
| Publications: | A Short and Efficient Synthesis of the Anti-Tuberculosis Agent Pretomanid from (R)-Glycidol T. Lucas, J.-P. Dietz, F. Cardoso, D. Snead, R. Nelson, K. Donsbach, F. B. Gupton, T. Opatz, Org. Process Res. Dev., 2023, accepted. Pharmacology, prevalence in Germany, and analytical data of cyclobutylmethyl- and norbornylmethyl-type synthetic cannabinoid receptor agonists B. Pulver, J. Riedel, T. Schönberger, S. Halter, T. Lucas, T. Opatz, K. E. Grafinger, M. Scheu, A. Zschiesche, M. Pütz, K. Putzer, F. Westphal, V. Auwärter, Drug Test Anal., 2023, 1-8. Diastereoselectivity is in the Details: Minor Changes Yield Major Improvements to the Synthesis of Bedaquiline S. J. Mear, T. Lucas, G. P. Ahlqvist, J. M. S. Robey, J.-P. Dietz, P. V. Khairnar, S. Maity, C. L. Williams, D. R. Snead, R. C. Nelson, T. Opatz, T. F. Jamison, Chem. Eur. J., 2022, 28, e202201311. Structure elucidation of the novel synthetic cannabinoid Cumyl-tosyl-indazole-3-carboxamide (Cumyl-TsINACA) found in illicit products in Germany B. Pulver, T. Schönberger, D. Weigel, M. Köck, Y. Eschenlohr, T. Lucas, N. Podlesnik, T. Opatz, W. Dreiseitel, M. Pütz, J. Schäper, V. Auwärter, F. Westphal, Drug Test. Anal., 2022, 1–20. Six-Step Gram Scale Synthesis of the HIV Integrase Inhibitor Dolutegravir Sodium J.-P. Dietz, T. Lucas, J. Groß, S. Seitel, J. Brauer, D. Ferenc, B. F. Gupton, T. Opatz, Org. Process Res. Dev. 2021, 25, 1898–1910.
A Concise Route to MK-4482 (EIDD-2801) from Cytidine Glucose as an eco‐friendly reductant in a one‐pot synthesis of 2,3‐dihydroquinazolin‐4(1H)‐ones Total synthesis and biological evaluation of seven new anti-inflammatory oxacyclododecindione-type macrolactones
Synthesis of 4-Amino-5-fluoropyrimidines and 5-Amino-4-fluoropyrazoles from a β-Fluoroenolate Salt
Visible Light Enables Aerobic Iodine Catalyzed Glycosylation
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