Dr. Jule Dietz

Diastereoselectivity is in the Details: Minor Changes Yield Major Improvements to the Synthesis of Bedaquiline

S. J. Mear, T. Lucas, G. P. Ahlqvist, J. M. S. Robey, J.-P. Dietz, P. V. Khairnar, S. Maity, C. L. Williams, D. R. Snead, R. C. Nelson, T. Opatz, T. F. Jamison, Chem. Eur. J., 2022, 28, e202201311.

Six-Step Gram Scale Synthesis of the HIV Integrase Inhibitor Dolutegravir Sodium

J.-P. Dietz, T. Lucas, J. Groß, S. Seitel, J. Brauer, D. Ferenc, B. F. Gupton, T. Opatz, Org. Process Res. Dev. 2021, 25, 1898–1910.

The di-tert-Butyl Phosphonate Route to the Antiviral Drug Tenofovir

J.-P. Dietz, D. Ferenc, T. Jamison, F. B. Gupton, T. Opatz, Org. Process Res. Dev. 2021, 25, 789–798.

A Concise Route to MK-4482 (EIDD-2801) from Cytidine
N. Vasudevan, G. Ahlqvist, C. P. McGeough, D. J. Paymode, F. S. P. Cardoso, T. Lucas, J.-P. Dietz, T. Opatz, T. F. Jamison, B. F. Gupton,D. R. Snead, Chem. Commun., 2020, 56, 13363-13364.

An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-based HIV Medicines
B. P. Derstine, J. W. Tomlin, C. Peck,  J.-P. Dietz, B. T. Herrera, F. Cardoso, D. J. Paymode, A. C. Yue, A. J. Arduengo, T. Opatz, D. Snead, R. W. Stringham, D. T. McQuade, B. F. Gupton, Org. Process Res. Dev., 2020, 24 1420−1427.

Synthesis of 4-Amino-5-fluoropyrimidines and 5-Amino-4-fluoropyrazoles from a β-Fluoroenolate Salt
T. Lucas, J.-P. Dietz, T. Opatz, Beilstein J. Org. Chem. 2020, 16, 445–450.

Synthesis of 5-Fluorocytosine using 2-Cyano-2-fluoroethenolate as a Key Intermediate
J.-P. Dietz, B. P. Derstine, D. Ferenc, E. T. Crawford, A. J. Arduengo, III, B. F. Gupton, D. T. McQuade, T. Opatz, Eur. J. Org. Chem. 2019, 5519-5526.

A Highly Active System for the Metal-Free Aerobic Photocyanation of Tertiary Amines with Visible Light: Application to the Synthesis of Tetraponerines and Crispine A
J. C. Orejarena Pacheco, A. Lipp, A. M. Nauth, F. Acke, J.-P. Dietz, T. Opatz
Chem. Eur. J. 2016, 22, 5409-5415.