Publications

Synthesis, Analytical Characterization, and Human CB₁ Receptor Binding Studies of the Chloroindole Analogues of the Synthetic Cannabinoid MDMB-CHMICA

S. Münster-Müller, S. Hansen, T. Lucas, A. Giorgetti, L. Mogler, S. Fischmann, F. Westphal, V. Auwärter, M. Pütz, T. Opatz, Biomolecules, 2024, 14, 1414.

Acremochlorin S and Other Prenylated Chlorophenol Antimicrobial Metabolites from the Fungus Acremonium sp. Strain MNA-F-1

M. S. Elnaggar, N. M. Mostafa, A. M. Elissawy, K. Phutthacharoen, P. Eckhardt, B. Sandargo, L. van Geelen, S. S. Ebada, T. Opatz, A. N. B. Singab, R. Kalscheuer, Fitoterapia, 2024, 179, 106254.

Synthesis of 3-substituted pyrrolidin-2-ones and 3-substituted piperidin-2-ones from esters

L. Brunotte, L. Beckmann, M. Ljiljanic, T. Opatz, Arkivoc, 2024, 1, 202412235.

Rhizomes of Rumex abyssinicus Jacq.: Unveiling five new anthraquinones (Rumabynosides A–E) and a review on hepatoprotective potential of its phytochemicals

L. T. Lonkeng, P. Eckhardt, B. T. Tsafack, R. Forster, B. K. Ponou, R. B. Teponno, T. B. Nguelefack, T. Opatz, L. A. Tapondjou, Phytochem. Lett., 2024, 64, 30-36.

The Photoredox Paradox: Electron and Hole Upconversion as the Hidden Secrets of Photoredox Catalysis

I. V. Alabugin, P. Eckhardt, K. M. Christopher, T. Opatz, J. Am. Chem. Soc., 2024, 146, 40, 27233–27254 (Perspective).

Versatile Metal-Free Arylation of BODIPY and Bis(BF₂) Chromophores by Using Arylazosulfones in a Sunflow System

S. M. Gil de Melo, T. dos Santos, D. G. Silva, Y. A. Martins, P. Eckhardt, R. F. V. Lopez, T. Opatz, S. Protti, F. da Silva Emery, Chem. Eur. J., 2024, accepted.

Substitution-induced Mechanistic Switching in SNAr-Warheads for Cysteine Proteases

C. Zimmer, J. Brauer, D. Ferenc, J. Meyr, P. Müller, H. J. Räder, B. Engels, T. Opatz, T. Schirmeister, Molecules, 2024, 29, 2660.

Introducing targeting units or pH-Releasable immunodrugs into Core-Clickable nanogels

A. G. Heck, D. Schwiertz, Be. Lantzberg, H.-C. Nguyen, R. Forster, M. Scherger, T. Opatz, J. A. Van Ginderachter, L. Nuhn, Eur. Polym. J., 2024, accepted.

Mechanistic Investigations of Polyaza[7]helicene in Photoredox and Energy Transfer Catalysis

J. Rocker, T. J. B. Zähringer, M. Schmitz, T. Opatz, C. Kerzig, Beilstein J. Org. Chem., 2024, accepted.

Solving A Mystery with Classical and Dual Photoredox Catalysis: Application of Nickel in the Synthesis of Ergot Alkaloids

J. Brauer, R. Wiechert, A. Hahn, T. Opatz, Org. Lett., 2024, 26, 4314–4317.

Esterification of Cyclic N6-threonylcarbamoyladenosine during RNA Sample Preparation

L. Bessler, J. Sirleaf, C. J. Kampf, K. Frankowska, G. Leszczyńska, T. Opatz, M. Helm, ChemMedChem, 2024, e202400115.

Total Synthesis of (±)-Oxacyclododecindione

K. Seipp, V. Grölz, H. Glass, E. Quraishi, N. Vierengel, T. Opatz, J. Org. Chem., 2024, 89, 5746–5763.

Total Synthesis, Structure Reassignment, and Biological Evaluation of the Anti-Inflammatory Macrolactone 13-Hydroxy-14-deoxyoxacyclododecindione

K. Seipp, C. Kammler, N. Rossdam, P. Eckhardt, A. Kiefer, G. Erkel, T. Opatz, J. Nat. Prod., 2024, 87, 1131–1149.

Reversible oxidative dimerization of 4-thiouridines in tRNA isolates

L. Bessler, J. Groß, C. J. Kampf, T. Opatz, M. Helm, RSC Chem. Biol., 2024, Advance Article.

Pyrroloquinolones B–F: Five unusual alkaloids from Vernonia glabra (Steetz) Vatke (Asteraceae)

V. K. Takeuneu, P. Eckhardt, B. T. Tsafack, U. J. Tsopmene, B. K. Ponou, J. P. Dzoyem, R. B. Teponno, T. Opatz, L. A. Tapondjou, Phytochem., 2024, 220, 114010.

Two new steroids from the medicinal plant Physalis peruviana L.  

L. W. Demgne, P. Eckhardt, B. Y. Kianfé, R. T. Tchuenguem, J. P. Dzoyem, B. K. Ponou, R. B. Teponno, L. Barboni, T. Opatz, L. A. Tapondjou, Phytochem. Lett., 2024, 59, 5-9.

One-pot Synthesis of CRBN PROTACs via Photoinduced C(sp2)C(sp3) Cross Coupling and Amide Formation for PROTAC Library Synthesis.

C. M. Arndt, J. Bitai, J. Brunner, T. Opatz, P. Martinelli, A. Gollner, K. R. Sokol, M. Krumb, J. Med. Chem., 2023, accepted.

NMR and Docking Calculations Reveal Novel Atomistic Selectivity of a Synthetic High-Affinity Free Fatty Acid vs. Free Fatty Acids in Sudlow’s Drug Binding Sites in Human Serum Albumin

T. Venianakis, A. Primikyri, T. Opatz, S. Petry, G. Papamokos, I. P. Gerothanassis, Molecules, 2023, 28(24), 7991.

Discovery and characterization of a broderol-like illudin, Omphaderol in the mycelial extracts of Omphalotus mexicanus (Omphalotaceae) using UPLC-QTOF-MS and NMR spectroscopy

P. Eckhardt, S. Reinecke, T. Opatz, M. Stadler, B. Sandargo, Phytochem. Anal., 2023, 1-7.

A Short and Efficient Synthesis of the Anti-Tuberculosis Agent Pretomanid from (R)-Glycidol

T. Lucas, J.-P. Dietz, F. Cardoso, D. Snead, R. Nelson, K. Donsbach, F. B. Gupton, T. Opatz, Org. Process Res. Dev., 2023, 27(9), 1641-1651.

Total Synthesis of Lamellarin G Trimethyl Ether through Enaminone Cyclocondensation

U. Šachlevičiūtė, N. Kleizienė, A. Bieliauskas, A. Šačkus, T. Opatz, Org. Biomol. Chem., 2023, 21, 5997-6007.

A new phenolic glycoside from the leaves of Flacourtia flavescens Willd.

D. C. N. Jouogo, P. Eckhardt, J.-D.-D. Tamokou, G. M. Takongmo, L. Voutquenne-Nazabadioko, T. Opatz, L. A. Tapondjou, D. Ngnokam, R. B. Teponno, Nat. Prod. Res., 2023, 0, 1-11.

Structure elucidation and biological activities of perylenequinones from an Alternaria species

A. Kiefer, M. Arnholdt, V. Grimm, L. Geske, J. Groß, N. Vierengel, T. Opatz, G. Erkel, Mycotoxin Res., 2023, 39, 303-316.

Copper-Catalyzed Synthesis of Pyrrolo[1,2-c]quinazolines and Pyrrolo[2,1-a]isoquinolines and Antiplasmodial Evaluation

N. M. Moreira, I. T. de Miranda, J. R. N. dos Santos, T. Opatz, G. Oliva, R. V. C. Guido, A. G. Corrêa, J. Org. Chem., 2023, 88(13), 8781–8790.

The macrocyclic lactone Oxacyclododecindione reduces fibrosis progression

S. Saurin, M. Meineck, M. Rohr, W. Roth, T. Opatz, G. Erkel, A. Pautz, J. Weinmann-Menke, Front. Pharmacol. Sec. Renal Pharmacology, 2023, 14, 1-14.

An In Vitro Study of Local Oxygen Therapy as Adjunctive Antimicrobial Therapeutic Option for Patients with Periodontitis

L. K. Müller-Heupt, A. Eckelt, J. Eckelt, J. Groß, T. Opatz, N. Kommerein, Antibiotics, 2023, 12(6), 990.

Substitution Effects on the Photophysical and Photoredox Properties of Tetraaza[7]helicenes

J. Rocker, J. A. Dresel, L. A. Krieger, P. Eckhardt, A. M. Ortuño, W. R. Kitzmann, G. H. Clever, K. Heinze, T. Opatz, Chem. Eur. J., 2023, 29, e2023012.

Comparison of Different Density Functional Theory Methods for the Calculation of Vibrational Circular Dichroism Spectra

J. Groß, J. Kühlborn, S. Pusch, C. Weber, L. Andernach, G. Renzer, P. Eckhardt, J. Brauer, T. Opatz, Chirality, 2023, 1-13.

Diplomeroterpenoid G: An unusual meroterpenoid from Mimosa pudica Linn. (Mimosaceae)

C. F. Kenmogne, P. Eckhardt, R. T. Tchuenguem, J. Groß, F. T. Ngouafong, B. K. Ponou, J. P. Dzoyem, R. B. Teponno, T. Opatz, L. A. Tapondjou, Tetrahedron, 2023, 120, 154451.

Oxygen-Releasing Hyaluronic-Acid Based Dispersion with Controlled Oxygen Delivery for Enhanced Periodontal Tissue Engineering

L. K. Müller-Heupt, N. Wiesmann-Imilowski, S. Schröder, J. Groß, P. C. Ziskoven, P. Bani, P. W. Kämmerer, E. Schiegnitz, A. Eckelt, J. Eckelt, U. Ritz, T. Opatz, B. Al-Nawas, C. Synatschke, J. Deschner, Int. J. Mol. Sci., 2023, 24, 5936.

Total Synthesis and Biological Evaluation of the Anti-Inflammatory (13R,14S,15R)-13-Hydroxy-14-deoxyoxacyclododecindione

K. Seipp, J. Groß, A. Kiefer, G. Erkel, T. Opatz, J. Nat. Prod., 2023, 86, 924–938.

A New Bacterial Adenosine-Derived Nucleoside as an Example of RNA Modification Damage

L. Bessler, L.-M. Vogt, M. Lander, C. Dal Magro, P. Keller, J. Kühlborn, C. J. Kampf, T. Opatz, M. Helm, Angew. Chem., 2023, 62, e202217128.

Complementary Mechanochemical and Biphasic Approaches for the Synthesis of Organic Thiocyanates using Hexacyanoferrates as Non-Toxic Cyanide Sources

C. Grundke, J. Groß, N. Vierengel, J. Sirleaf, M. Schmitz, L. Krieger, T. Opatz, Org. Biomol. Chem., 2023, 21, 644-650.

Xylochemical Synthesis and Biological Evaluation of the Orchidaceous Natural Products Isoarundinin I, Bleochrin F, Blestanol K and Pleionol

L. Geske, J. Baier, J. Boulos, T. Efferth, T. Opatz, J. Nat. Prod., 2023, 86, 131–137.

Syntheses of Isatins and Oxindoles Derivatives as SARS-CoV-2 Inhibitors Evaluated
through Phenotypic Screening with Vero Cells

C. M. C. F. Lima, L. H. Freitas-Junior, C. B. Moraes, C. G. Barbosa, T. Opatz, M. M. Victor, J. Braz. Chem. Soc., 2023, 0, 1-9.

Pharmacology, prevalence in Germany, and analytical data of cyclobutylmethyl- and norbornylmethyl-type synthetic cannabinoid receptor agonists

B. Pulver, J. Riedel, T. Schönberger, S. Halter, T. Lucas, T. Opatz, K. E. Grafinger, M. Scheu, A. Zschiesche, M. Pütz, K. Putzer, F. Westphal, V. Auwärter, Drug Test Anal., 2023, 1-8.

Extracts of Rheum palmatum and Aloe vera Show Beneficial Properties for the Synergistic Improvement of Oral Wound Healing

L. K. Müller-Heupt, N. Wiesmann, S. Schröder, Y. Korkmaz, N. Vierengel, J. Groß, R. Dahm, J. Deschner, T. Opatz, J. Brieger, B. Al-Nawas, P. W. Kämmerer, Pharmaceutics, 2022, 14, 2060.

Growth vector elaboration of fragments: regioselective functionalization of 5-hydroxy-6-azaindazole and 3-hydroxy-2,6-naphtyridine

Jr. P. Eliandro da Silva, S. Melo, M. Helder de Paula, R. Vessecchi, T. Opatz, J. Day, A. Ganesan, F. da Silva Emery, Org. Biomol. Chem., 2022, 20, 7483-7490.

Two Paths to Oxidative C−H Amination Under Basic Conditions: A Theoretical Case Study Reveals Hidden Opportunities Provided by Electron Upconversion

P. Eckhardt, Q. Elliott, I. Alabugin, T. Opatz, Chem. Eur. J., 2022, 28, e202201637.

An Iodide-mediated Anodic Amide Coupling

L. M. Großmann, V. Beier, L. Duttenhofer, L. Lennartz, T. Opatz, Chem. Eur. J., 2022, 28, e202201768.

Alternatives to Iridium: A Polyaza[7]helicene as a Strongly Reductive Visible Light Photoredox Catalyst

J. Rocker, T. Opatz, ACS Org. Inorg. Au, 2022, 2, 415–421.

Diastereoselectivity is in the Details: Minor Changes Yield Major Improvements to the Synthesis of Bedaquiline

S. J. Mear, T. Lucas, G. P. Ahlqvist, J. M. S. Robey, J.-P. Dietz, P. V. Khairnar, S. Maity, C. L. Williams, D. R. Snead, R. C. Nelson, T. Opatz, T. F. Jamison, Chem. Eur. J., 2022, 28, e202201311.

A General Electro-Synthesis Approach to Amaryllidaceae Alkaloids

D. Pollok, L. M. Großmann, T. Behrendt, T. Opatz, S. R. Waldvogel, Chem. Eur. J., 2022, 28, e2022015.

Ethyl Hydroxyethyl Cellulose—A Biocompatible Polymer Carrier in Blood

A. Eckelt, F. Wichmann, F. Bayer, J. Eckelt, J. Groß, T. Opatz, K. Jurk, C. Reinhardt, K. Kiouptsi, Int. J. Med. Sci., 2022, 23, 6432.

Constituents of Desmodium salicifolium (Poir.) DC (Fabaceae) with antifungal activity

A. P. T. Donkia, P. Eckhardt, B. T. Tsafack , R. T. Tchuenguem, J. Groß, B. K. Ponou, R. B. Teponno, J. P. Dzoyem, T. Opatz, L. Barboni, L. A. Tapondjou, Phytochem. Lett., 2022, 50, 100-105.

Sesquiterpene Lactones from Vernonia tufnelliae: Structural Features, Stereochemistry, and Biological Evaluation

G. Bitchagno, A. Schueffler, J. Groß, M. Krumb, P. Tané, T. Opatz, J. Nat. Prod., 2022, 85, 1681-1690.

The ADEBAR project – European and international provision of analytical data from structure elucidation and analytical characterization of NPS

B. Pulver, S. Fischmann, M. Pütz, T. Schönberger, J. Schäper, D. Budach, A. Jacobsen-Bauer, W. Dreiseitel, J. Zagermann, A. Damm, S. Knecht, T. Opatz, V. Auwärter, F. Westphal, Drug. Test. Anal., 2022, 14, 1491-1502.

Synthesis of new substituted 7-azaisoindigos

C. M. C. F. Lima, T. Opatz, M. M. Victor, Results Chem., 2022, 4, 100363.

Antiplanktonic and Antibiofilm Activity of Rheum palmatum against Streptococcus oralis and Porphyromonas gingivalis

N. Kommerein, N. Vierengel, J. Groß, T. Opatz, B. Al-Nawas, L. K. Müller-Heupt, Microorganisms, 2022, 10, 965.

Drug candidates for autoimmune Diseases

S. Saurin, M. Meineck, G. Erkel, T. Opatz, J. Weinmann-Menke, A. Pautz, Pharmaceuticals, 2022, 15, 503.

Photochemical α-Aminonitrile Synthesis using Zn-Phthalocyanines as Near-Infrared Photocatalysts

C. Grundke, R. Silva, W. Kitzmann, K. Heinze, K. de Oliveira, T. Opatz, J. Org. Chem., 2022, 87, 5630–5642.

Antimicrobial activities of extract, fractions and compounds from the medicinal plant Helichrysum odoratissimun (L.) Sweet (Asteraceae)

P. V. K. Sinda, R. T. Tchuenguem, B. K. Ponou, J. Kühlborn, B. Y. Kianfe, J. P. Dzoyem, R. B. Teponno, T. Opatz, L. Barboni, L. A. Tapondjou, S. Afr. J. Bot., 2022, 147, 937.

Structure elucidation of the novel synthetic cannabinoid Cumyl-tosyl-indazole-3-carboxamide (Cumyl-TsINACA) found in illicit products in Germany

B. Pulver, T. Schönberger, D. Weigel, M. Köck, Y. Eschenlohr, T. Lucas, N. Podlesnik, T. Opatz, W. Dreiseitel, M. Pütz, J. Schäper, V. Auwärter, F. Westphal, Drug Test. Anal., 2022, 1–20.

Muellerilactone and other bioactive constituents of Phyllanthus muellerianus (kuntze) exell

B. Tsakem, P. Eckhardt, R. T. Tchuenguem, B. K. Ponou, J. P. Dzoyem, R. B. Teponno, T. Opatz, L. Barboni, L. A. Tapondjou, Biochem. Syst. Ecol., 2022, 101, 104397.

A dinorcassane-type diterpene and a steroidal saponin from Distemonanthus benthamianus Baill. (Caesalpiniaceae)

R. V. K. Tchebou, P. Eckhardt, B. M. Kemkuignou, R. Tchuenguem, R. T. Fouedjou, B. K. Ponou, J. P. Dzoyem, R. B. Teponno, L. Barboni, T. Opatz, L. A. Tapondjou, Phytochem. Lett., 2022, 48, 62-67.

Vinylcyclopropane [3+2] Cycloaddition with Acetylenic Sulfones Based on Visible Light Photocatalysis

A. Luque, J. Groß, T. J. B. Zähringer, C. Kerzig, T. Opatz, Chem. Eur. J., 2022, 28, e2021043.

Antimicrobial Activity of Eucalyptus globulus, Azadirachta indica, Glycyrrhiza glabra, Rheum palmatum Extracts and Rhein against Porphyromonas gingivalis
L. K. Müller-Heupt, N. Vierengel, J. Groß, T. Opatz, J. Deschner, F. D. von Loewenich, Antibiotics, 2022, 11, 186.

Anti-inflammatory dihydroxanthones from a Diaporthe species
M. Rohr, U. Kauhl, J. Groß, T. Opatz, G. Erkel, Biol. Chem., 2022, 403, 89-101.

Mimonoside D: A new triterpenoid saponin from Mimosa diplotricha Sauvalle (Fabaceae)

C. F. Kenmogne, B. K. Ponou, B. M. Kemkuignou, J. Kühlborn, R. T. Tchuenguem, R. B. Teponno, J. P. Dzoyem, T. Opatz, M. Stadler, L. A. Tapondjou, Nat. Prod. Res. 2021, 1-9.

Regioselective, electrochemical synthesis of heterocyclic α-amino amides

S. R. Waldvogel, S. Arndt, D. Weis, K. Donsbach, A. M. Nauth, T. Opatz, PCT Int. Appl. 2021, WO2021214278.

Nickel-Mediated Photoreductive Cross Coupling of Carboxylic Acid Derivatives for Ketone Synthesis
J. Brauer, E. Quraishi, L. M. Kammer, T. Opatz, Chem. Eur. J., 2021, 27, 18168-18174.

Marine Pyrrole Alkaloids
K. Seipp, L. Geske, T. Opatz, Mar. Drugs, 2021, 19, 514.

Xylochemicals and Where to Find Them

J. Groß, C. Grundke, J. Rocker, A. J. Arduengo III, T.Opatz, Chem. Commun. 2021, 57, 9979-9994.

Chemical constituents, total phenolic content, antioxidant activity and bactericidal effect of Dicliptera verticillate (Acanthaceae)

P. Y. Mbopi, H. D. S. Fozeng, Y. M. M. Nguekeu, G. T. M. Bitchagno, C. B. N. Ngantchouko, M. D.  Awouafack, T. Opatz, S. A. Ngouela, H. Morita, M. Tene, S. Afr. J. Bot. 2021, 142, 216-221.

Activation of Chemical Substrates Under Sustainable Conditions: Electrochemistry and Electrocatalysis

L. M. Großmann, T. Opatz, in Sustainable Organic Synthesis: Tools and Strategies, Vol. 1 (Eds.: S. Protti, A. Palmieri), The Royal Society of Chemistry, 2021, vol. 1, 119-149.

Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure–Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies

S. Jung, N. Fuchs, P. Johe, A. Wagner, E. Diehl, T. Yuliani, C. Zimmer, F. Barthels, R. Zimmermann, P. Klein, W. Waigel, J. Meyr, T. Opatz, S. Tenzer, U. Distler, H. J. Räder, C. Kersten, B. Engels, U. Hellmich,  J. Klein, T. Schirmeister, J. Med. Chem. 2021, 64, 12322-12358.

Programmed Formation of HCN Oligomers through Organosulfur Catalysis
C. Grundke, C. Kong, C. Kampf, B. F. Gupton, D. T. McQuade and T. Opatz, J. Org. Chem. 2021, 86, 15, 10320-10329.

Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of Pentaclethra macrophylla Benth (Mimosaceae)
P. V. K. Sinda, B. K. Ponou, B. T. Tsafack, J. Kühlborn, R. T. Tchuenguem, R. B. Teponno, J. P. Dzoyem, T.  Opatz, L. A. Tapondjou, Advances in Biological Chemistry, 2021, 11, 126-141.

Six-Step Gram Scale Synthesis of the HIV Integrase Inhibitor Dolutegravir Sodium

J.-P. Dietz, T. Lucas, J. Groß, S. Seitel, J. Brauer, D. Ferenc, B. F. Gupton, T. Opatz, Org. Process Res. Dev. 2021, 25, 1898–1910.

Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G

L. Geske, U. Kauhl, M. E. M. Saeed, A. Schüffler, E. Thines, T. Efferth, T. Opatz, Molecules, 2021,26, 3224.

Facile Access to Foldable Redox-Active Flavin-Peptide Conjugates
F. Stricker, J. C. Kölsch, S. B. Beil, S. Preiß, S. R. Waldvogel, T. Opatz and P. Besenius, Org. Biomol. Chem. 2020, 19, 4483-4486.

Synthesis of Morphinans through Anodic Aryl-Aryl Coupling

N. Vierengel, L. Geske, E. Sato, T. Opatz, Chem. Rec. 2021, 21, 1 – 11.

Trials for gathering information on an unknown peak in the GC-MS spectra of horse and pony hair extracts

M. Tsikolia, T. Opatz, U. Kauhl, N. Tabanca, B. Demirci, S. H. TenBroeck, Kenneth J. Linthicum, U. R. Bernier, Adv. Entomol. 2021, 9, 100-111.

C-28/C-30 oxidized cycloartanes from the leaves and twigs of Caloncoba dusenii Gilg

L. Zeufack Nguetsa, J. D. Simo Mpetga, G. T. M. Bitchagno, J. Delain Tadjuidje, J. Groß,  B.N. Lenta, T. Opatz, N. Sewald, M. Tene, Phytochem. Lett., 2021, 43, 145-149.

The di-tert-Butyl Phosphonate Route to the Antiviral Drug Tenofovir

J.-P. Dietz, D. Ferenc, T. Jamison, F. B. Gupton, T. Opatz, Org. Process Res. Dev. 2021, 25, 789–798.

One-Pot Oxidative C–H Activation / Aza-Prins-Type Reaction of Tertiary Alkynylamines: A Counter Ion-Induced Iminium Ion–Alkyne Cyclization

J. Orejarena Pacheco, S. Pusch, L. Geske, T. Opatz, J. Org. Chem., 2021, 86, 3, 2760–2771.

Hepatoprotective effects of extracts, fractions and compounds from the stem bark of Pentaclethra  macrophylla Benth: Evidence from in vitro and in vivo studies

C. L. K. Bomgning, P. V. K. Sinda, B. K. Ponou, A. L. Fotio, M. K. Tsague, B. T. Tsafack, J. Kühlborn, E. P. Mbuyo-Nguelefack, R. B. Teponno, T. Opatz, L. A. Tapondjou, T. B. Nguelefack, Biomed. Pharmacother. 2021, 136, 111242.

Diels-Alder Reaction of β-Fluoro-β-nitrostyrenes with Cyclic Dienes

S. A. Ponomarev, R. V. Larkovich, A. S. Aldoshin, A. A. Tabolin, S. L. Ioffe, J. Groß,, T. Opatz, V. G. Nenajdenko, Beilstein J. Org. Chem., 2021, 17, 283–292.

Hantzsch Ester-mediated Photochemical Transformations in the Ketone Series: Remote C(sp3)−H Arylation and Cyclopentene Synthesis through Strain Release

J. Paternoga, J. Kühlborn, N. O. Rossdam, T. Opatz, J. Org. Chem., 2021, 86, 4,  3232–3248.

The sustainable synthesis of levetiracetam by an enzymatic dynamic kinetic resolution and an ex-cell anodic oxidation

S. Arndt, B. Grill, H. Schwab, G. Steinkellner, U. Pogorevčnik, D. Weis, A. M. Nauth, T. Opatz, K. Donsbach, S. R. Waldvogel and M. Winkler, Green Chem., 2021, 23, 388-395.

Photoredox-catalyzed synthesis of N-unsubstituted enaminosulfones from vinyl azides and sulfinates

O. M. Mulina, A. I. Ilovaisky, T. Opatz and A. O. Terent’ev, Tetrahedron Lett., 2020, 64, 152737.

Synthesis of Optically Active Hydroxyalkyl Cycloheptatrienes: A Key Step in the Total Synthesis of 6,11-Methylene-LXB4

A. Nava, L. Trippe, A. Frank, L. Andernach, T. Opatz and U. Nubbemeyer, Synlett, 2020, 32, 45 -50.

Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity

H. S. D. Chouna, J. J. K. Bankeu, Y. S. F. Fongang, D. Dize, B. K. Ponou, G. T. M. Bitchagno, A. F. Awantu, B. N. Lenta, F. B. Fekam, S. A. Ngouela, T. Opatz and N. Sewald, Phytochemistry Letters, 2021, 41, 14-20.

Strain Release Chemistry of Photogenerated Small‐Ring‐Intermediates
A. Luque, J. Paternoga, T. Opatz, Chem. Eur. J. 2020, 27, 4500 –4516.

An insight into the synthesis of N-methylated polypeptides

C.Muhl, L. Zengerling, J. Groß, P. Eckhardt, T. Opatz, P. Besenius, M. Barz, Polym. Chem., 2020, 11, 6919-6927.

2-Cyano-2-fluoroethenolate Salts (CFES): Versatile Active Pharmaceutical Intermediates
T. Opatz, US-Patent 2020 20200262785.

A Concise Route to MK-4482 (EIDD-2801) from Cytidine
N. Vasudevan, G. Ahlqvist, C. P. McGeough, D. J. Paymode, F. S. P. Cardoso, T. Lucas, J.-P. Dietz, T. Opatz, T. F. Jamison, B. F. Gupton,D. R. Snead, Chem. Commun., 2020, 56, 13363-13364.

Multivalency beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells
M. Krumb, M. L. Frey, J. Langhanki, R. Forster, D. Kowalczyk, V. Mailänder, K. Landfester, T. Opatz, Cells, 2020, 2087.
This article is a contribution within the CRC1066 and appears in the special issue: Nanoparticles in Cancer Immunotherapy

Glucose as an eco‐friendly reductant in a one‐pot synthesis of 2,3‐dihydroquinazolin‐4(1H)‐ones
T. dos Santos, C.Grundke, T. Lucas, L. Großmann, G. C. Clososki, T. Opatz, Eur. J. Org. Chem., 2020, 6429-6432.

Antimicrobial secondary metabolites from the medicinal plant Crinum glaucum A. Chev. (Amaryllidaceae)
B. Y. Kianfé, J. Kühlborn, R.T. Tchuenguem B. T. Tchegnitegni, B. K. Ponou, J. Groß, R. B.Teponno, J. P. Dzoyem, T. Opatz, L. A.Tapondjou, S. Afr. J. Bot, 2020, 161-166.

Total synthesis and biological evaluation of seven new anti-inflammatory oxacyclododecindione-type macrolactones
C. Weber, N. Vierengel, T. Walter, T. Behrendt, T. Lucas, G. Erkel and T. Opatz, Org. Biomol. Chem., 2020, 18, 5906-5917.

α-Aminonitriles: From Sustainable Preparation to Applications in Natural Product Synthesis
C.Grundke, N. Vierengel, T. Opatz, Chem. Rec. 2020, 20, 989–1016.

New Alkenylresorcinols with Cytotoxic and Antimicrobial Activities from the Leaves of Embelia schimperi
T. A. M. Togue, B. L. Ndontsa, G. T. M. Bitchagno, A. Schüffler, T. Opatz, P. Tane, M. Tene, Planta Med.  2020, 86, 1298-1303.

An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-based HIV Medicines
B. P. Derstine, J. W. Tomlin, C. Peck,  J.-P. Dietz, B. T. Herrera, F. Cardoso, D. J. Paymode, A. C. Yue, A. J. Arduengo, T. Opatz, D. Snead, R. W. Stringham, D. T. McQuade, B. F. Gupton, Org. Process Res. Dev., 2020, 24 1420−1427.

Total Synthesis of a Partial Structure from Arabinogalactan and its Application for Allergy-Prevention
M. Krumb, M. Jäger, A. Voss, L. Immig, K. Peters, D. Kowalczyk, A. Bufe, T. Opatz, O. Holst, C. Vogel, M. Peters, Chem. Eur. J., 2021, 27, 928.

This article was selected as "Hot Paper" and as Cover Picture of Chemistry - A European Journal.

A new ceramide from the leaves of Lannea schimperi
R. T. Nguemo, R. Mbouangouere, G. T. M. Bitchagno, R. Tchuenguem, E. V. N.Temgoua, B. L. Ndontsa, J. S. Mpetga, T. Opatz, A. S. Ngouela, P. Tane, Nat. Prod. Res., 2020, 36, 515-522.

Applications of Xylochemistry from Laboratory to Industrial Scale
J. Groß, J. Kühlborn, T. Opatz, Green Chem. 2020, 22, 4411-4425.

Antisalmonellal Activities of Extracts, Fractions, Compounds and Semi-synthetic Flavonoid Derivatives from Tristemma hirtum P. Beauv (Melastomataceae)

J. N. Kenfack, D. T. Ngoudjou, B. K. Ponou, J. Kühlborn, B. T. Tsafack, R. B. Teponno, T. Opatz, L. Barboni, D. Gatsing, L. A. Tapondjou, Science Journal of Chemistry. 2020, 8, 48-58.

Copper-catalyzed one-pot synthesis of 3-(N-heteroarenyl)acrylonitriles through radical conjugated addition of β-nitrostyrene to methylazaarenes

N. M. Moreira, L. S. R. Martelli, K. I. R. de Julio, J. Zukerman-Schpector, T. Opatz, A. G. Corrêa, Eur. J. Org. Chem., 2020, 4563–4570.

Anodic Oxidation as an Enabling Tool for the Synthesis of Natural Products
L. Geske, E. Sato, T. Opatz, Synthesis, 2020, 52, 2781-2794.

Thoughts on What Chemists Can Contribute to Fighting SARS-CoV-2 - A Short Note on Hand Sanitizers, Drug Candidates and Outreach
T. Opatz, J. Senn-Bilfinger, C. Richert, Angew. Chem. Int. Ed., 2020, 59, 9236–9240.

Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases – Studies on Inhibition Mechanism and Kinetics
P. Klein, F. Barthels, P. Johe, A. Wagner, S. Tenzer, U. Distler, T. A. Le, P. Schmid, V. Engel, B. Engels, U. A. Hellmich, T. Opatz, T. Schirmeister, Molecules, 2020, 25, 2064.

Predicting 19 F NMR chemical shifts: A combined computational and experimental study of a trypasonomal oxidoreductase-inhibitor complex
J. C. B. Dietschreit, A. Wagner, T. Anh Le, P. Klein, H. Schindelin, T. Opatz, B. Engels, U. A. Hellmich, C. Ochsenfeld, Angew. Chem. Int. Ed. 2020, 59, 12669–12673.

New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and unexpected Prodrug Identification
P. Klein, P. Johé, A. Wagner, S. Jung, B. Engels, J. Kühlborn, S. Tenzer, U. Distler, W. Waigel, U. A. Hellmich, T. Opatz, T. Schirmeister, Molecules, 2020, 25, 1451.

Resolving Binding Events on the Multifunctional Human Serum Albumin

L. Wenskowsky, M. Wagner, J. Reusch, H. Schreuder, H. Matter, T. Opatz, S. M. Petry, ChemMedChem, 2020, 15, 738-743

Photoredox-Catalyzed Four Component Reaction for the Synthesis of Complex Secondary Amines

L. M. Kammer, M. Krumb, B. Spitzbarth, B. Lipp, J. Kühlborn, J. Busold, O. M. Mulina, A. O. Terentev and T. Opatz, Org. Lett. 2020, 22, 3318−3322. (Back Cover)

Synthesis of 4-Amino-5-fluoropyrimidines and 5-Amino-4-fluoropyrazoles from a β-Fluoroenolate Salt
T. Lucas, J.-P. Dietz, T. Opatz, Beilstein J. Org. Chem. 2020, 16, 445–450.

Targeting of Immune Cells with Trimannosylated Liposomes

K. Wagener, M. Bros, M. Krumb, J. Langhanki, S. Pektor, M. Worm, M. Schinnerer, E. Montermann, M. Miederer, H. Frey, T. Opatz, F. Rösch, Adv. Therap., 2020, 1900185

Erysacleuxins C and D, new isoflavones from the twigs of Erythrina sacleuxii Hua and their cytotoxic activity

J. O. Ombito, G. Bojase, R. R. T. Majinda, I. B. Masesane, A. Schüffler, T. Opatz, Arab. J. Chem. 2020, 13, 4019–4023.

Smooth Metal-free Photoinduced Preparation of Valuable 8-Arylxanthines
H. O. Abdulla, A. A. Amin, C. Raviola, T. Opatz, S. Protti, M. Fagnoni, Eur. J. Org. Chem. 2020, 1448–1452.

Synthesis of 2,3-Dihydro-4-Pyridones, 4-Quinolones and 2,3-Dihydro-4-Azocinones by Visible-Light Photocatalytic Aerobic Dehydrogenation
A. Sevenich, P. S. Mark, T. Behrendt, J. Groß, T. Opatz, Eur. J. Org. Chem. 2020, 1505–1514.
This article was selected as Very Important Paper and also appears in: Special Collection: Photochemical Synthesis and ChemSusChem Hot Topic: Sustainable Chemistry.

Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1

L. Zhao, R. M. Awori, M. Kaiser, J. Groß, T. Opatz, H. B. Bode, J. Nat. Prod. 2019, 82, 3499-3503.

Visible Light-Induced Cleavage of C–S bonds in Thioacetals and Thioketals with Iodine as a Photocatalyst
M. Krumb, L. M. Kammer, R. Forster, C. Grundke, T. Opatz, ChemPhotoChem. 2020,  4, 101 – 104.
This article was selected as Very Important Paper and also appears in: Hot Topic: Photocatalysis and Special collection: Photochemical Synthesis. (Cover Picture)

Neo-clerodane diterpenoids from Conyza pyrrhopappa Sch.Bip. ex A.Rich
G. T. M. Bitchagno, A. Schüffler, M. Krumb, P. Tane, T. Opatz, Nat. Prod. Res. 2019, DOI: 10.1080/14786419.2019.1690490.

Caffeate and piperidine-3-ol derivatives from the stem bark of Cassia sieberiana
B. C. K. Atontsa, G. T. M. Bitchagno, J. D. S. Mpetga, B. E. N. Wamba, P. Nayim, R. T. Tchuenguem, R. R. Koagne, T. Opatz, V. Kuete, P. Tane, Nat. Prod. Res. 2019, DOI: 10.1080/14786419.2019.1684278.

Making Natural Products from Renewable Feedstocks: Back to the Roots?
J. Kühlborn, J. Groß, T. Opatz, Nat. Prod. Rep. 2019. Review.

A Copper-Catalyzed Synthesis of Pyrroles through Photochemically Generated Acylazirines
J. Paternoga, T. Opatz, Eur. J. Org. Chem. 2019, 7067-7078.

Chemical recycling of polyenaminones by transamination reaction via amino–enaminone polymerisation/depolymerisation
A. Zupanc, T. Kotnik, U. Štanfel, H. B. Žugelj, A. Kristl, A. Ručigaj, L. Matoh, D. Pahovnik, U. Grošelj, T. Opatz, F. Požgan, B. Štefane, E. Žagar, J. Svete, Eur. Polym. J. 2019, 121, 109282.

A new polyketide from the bark of Hypericum roeperianum Schimp. (Hypericaceae)
F. Damen, O. M. F. Demgne, G. T. M. Bitchagno, I. Celik, J. D. S. Mpetga, S. B. Tankeo, T. Opatz, V. Kuete, P. Tane, Nat. Prod. Res. 2019, DOI: 10.1080/14786419.2019.1677655.

Flavans and other chemical constituents of Crinum biflorum (Amaryllidaceae)
B. Y. Kianfé, R. B. Teponno, J. Kühlborn, R. T. Tchuenguem, B. K. Ponou, S. E. Helaly, J. P. Dzoyem, T. Opatz, L. A. Tapondjou, Biochem. Syst. Ecol. 2019, 87, 103953.

A new ursane-type triterpene oxoglucopyranoside from Crossopteryx febrifuga
M. Kayangar, R. N. Nono, J. Kühlborn, R. Tchuenguem, B. K. Ponou, K. Jenett-Siems, R. B. Teponno, J. P. Dzoyem, T. Opatz, M. F. Melzig, L. A. Tapondjou, Z. Naturforsch. C, 2019, 74, 289–293.

Saponin with antibacterial activity from the roots of Albizia adianthifolia
G. Sonfack, C. F. Tchinda, I. K. Simo, G. T. M. Bitchagno, B. K. Nganou, İ. Çelik, M. Tene, S. F. Görkem, T. Opatz, V. Penlap Beng, V. Kuete, P. Tane, Nat. Prod. Res. 2019, DOI: 10.1080/14786419.2019.1672689.

Noncovalent targeting of nanocarriers to immune cells with polyphosphoester-based surfactants in human blood plasma
J. Simon, K. N. Bauer, J. Langhanki, T. Opatz, V. Mailänder, K. Landfester, F. R. Wurm, Adv. Sci. 2019, 6, 1901199.

Anthocleistenolide B, a New Secoiridoid from Anthocleista liebrechtsiana De Wild & T. Durand
F. T. Ngouafong, R. T. Tchuenguem, J. Kühlborn, B. T. Tchegnitegni, B. K. Ponou, R. B. Teponno, J. P. Dzoyem, T. Opatz, L. A. Tapondjou, Advances in Biological Chemistry, 2019, 9, 135-142.

(±) Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp.
Y.-N. Shi, S. Pusch, Y.-M. Shi, C. Richter, J. G. Macia-Vicente, H. Schwalbe, M. Kaiser, T. Opatz, H. B. Bode, J. Org. Chem. 2019, 84, 11203-11209.

A Xylochemically-Inspired Synthesis of Lamellarin G Trimethyl Ether via an Enaminone Intermediate
R. Klintworth, C. de Koning, T. Opatz, J. Michael, J. Org. Chem. 2019, 84, 11025-11031.

Valorisation of Cashew Nut Shell Liquid Phenolics in the Synthesis of UV Absorbers
K. Ngwira, J. Kühlborn, Q. Mgani, C. de Koning, T. Opatz, Eur. J. Org. Chem. 2019, 4778-4790.

Synthesis of 5-Fluorocytosine using 2-Cyano-2-fluoroethenolate as a Key Intermediate
J.-P. Dietz, B. P. Derstine, D. Ferenc, E. T. Crawford, A. J. Arduengo, III, B. F. Gupton, D. T. McQuade, T. Opatz, Eur. J. Org. Chem. 2019, 5519-5526.

Chemical profiling of the synthetic cannabinoid MDMB-CHMICA: identification, assessment and stability study of synthesis-related impurities in seized and synthesized samples
S. Münster-Müller, S. Hansen, T. Opatz, R. Zimmermann, M. Pütz, Drug Test. Analysis 2019, 11, 1192-1206.

Halogenated 2,1,3-benzoxadiazoles as Potential Fluorescent Warheads for Covalent Protease Inhibitors
A. Kuznetsova, P. Klein, T. Opatz, Proceedings 2019, 9, 54.

Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction
B. Lipp, L. M. Kammer, M. Kücükdisli, A. Luque, J. Kühlborn,
S. Pusch, G. Matulevičiūtė, D. Schollmeyer, A. Šačkus, T. Opatz, Chem. Eur. J. 2019, 8965–8969.
(Hot Paper) (cover picture)

HPMA-Based Nanocarriers for Effective Immune System Stimulation
S. Kramer, J. Langhanki, M. Krumb, T. Opatz, M. Bros, R. Zentel, Macromol. Biosci. 2019, 1800481.

Strecker Reactions with Hexacyanoferrates as non-toxic Cyanide Sources
C. Grundke, T. Opatz, Green. Chem. 2019, 21, 2362-2366.

Compounds having excited state intramolecular proton transfer (ESIPT) character for use in treating and/or preventing sunburn and/or preventing U.V. damage
T. Opatz, J. Kühlborn, C. B. De Koning, K. J. Ngwira, Q. A. Mgani, South African provisional patent application 2019  ZA2019/01514.

Visible Light Enables Aerobic Iodine Catalyzed Glycosylation
M. Krumb, T. Lucas, T. Opatz, Eur. J. Org. Chem. 2019, 4517-4521.
Front Cover of Issue 28.

Gold(II) Porphyrins in Photoinduced Electron Transfer Reactions
S. Preiß, A. Päpcke, L. Burkhardt, L. Großmann, S. Lochbrunner, M. Bauer, T. Opatz, K. Heinze,
Chem. Eur. J. 2019, 25, 5940-5949.

Total Synthesis of (−)-Oxycodone via Anodic Aryl–Aryl Coupling
A. Lipp, M. Selt, D. Ferenc, D. Schollmeyer, S. R. Waldvogel, T. Opatz, Org. Lett. 2019, 21, 1828–1831.
(Cover Picture)
Article was highlighted in Nature Reviews Chemistry and Synfacts.

Xylochemical Synthesis of Cytotoxic 2-Aminophenoxazinone-Type Natural Products Through Oxidative Cross Coupling
J. Kühlborn, M. Konhäuser, J. Groß, P. Wich, T. Opatz, ACS Sustainable Chem. Eng. 2019, 7, 4414–4419.

Inhibitor-induced dimerization of an essential oxidoreductase from African Trypanosomes
A. Wagner, T. A. Le, M. Brennich, P. Klein, N. Bader, E. Diehl, D. Paszek, A. K. Weickhmann, N. Dirdjaja, R. L. Krauth-Siegel, B. Engels, T. Opatz, H. Schindelin, U. A. Hellmich, Angew. Chem. 2019, 131, 3679-3683.

Bisbenzylisoquinoline Alkaloids
C. Weber, T. Opatz, The Alkaloids 2019, 81, 1-114.

Aromatic hydrocarbons as catalysts and mediators in photoinduced electron transfer reactions
B Lipp, T. Opatz, in Photochemistry, 46, The Royal Society of Chemistry, 2019, 370-394.

Photoredox-Alkenylation of Carboxylic Acids and Peptides: Synthesis of Covalent Enzyme Inhibitors
L. M. Kammer, B. Lipp, T. Opatz, J. Org. Chem., 2019, 84 (5), 2379–2392.
Article was selected for "ACS Editors' Choice" (View ACS LiveSlides presentation, Front Cover).

Total Synthesis of epi-Trichosetin
U. Kauhl, L. Andernach, T. Opatz, J. Org. Chem. 2018, 83, 15170–15177.

Protective Effects of Extracts, Isolated Compounds from Desmodium uncinatum and Semi-Synthetic Isovitexin Derivatives against Lipid Peroxidation of Hepatocyte’s Membranes
B. T. Tsafack, C. L. K. Boming, J. Kühlborn, R. T. Fouedjou, B. K. Ponou, R. B. Teponno, A. L. Fotio, L. Barboni, T. Opatz, T. B. Nguelefack, L. A. Tapondjou, Adv. Biol. Chem. 2018, 8, 101-120.

A New Flavonol Glycoside from Tristemma hirtum (Melastomataceae)
J. N. Kenfack, B. K. Ponou, J. Kühlborn, R. B. Teponno, R. N. Nono, R. T. Fouedjou, T. Opatz, H. J. Park, L. A. Tapondjou, Nat. Prod. Sci. 2018, 24, 213-218.

TiO2 Nanoparticles Functionalized with Non-Innocent Ligands Allow Oxidative Photocyanation of Amines with Visible/Near-Infrared Photons
A. M. Nauth, E. Schechtel, R. Dören, W. Tremel, T. Opatz, J. Am. Chem. Soc., 2018, 140, 14169–14177.

Non-toxic Cyanide Sources and Cyanating Agents
A. M. Nauth, T. Opatz, Org. Biomol. Chem., 2018, 17, 11-23. (Cover picture).

Chemical constituents from Anthocleista liebrechtsiana De Wild & T. Durand (Loganiaceae)
F. T. Ngouafong, R. T. Tchuenguem, J. Kühlborn, B. K. Ponou, R. B. Teponno, J. P. Dzoyem, T. Opatz, L. A. Tapondjou, Biochem. Syst. Ecol. 2018, 81, 17-20.

Flow Photochemistry of Azosulfones – Application of "Sunflow"-Reactors
P. E. da Silva Júnior, H. I. M. Amin, A. M. Nauth, F. da Silva Emery, S. Protti, T. Opatz, ChemPhotoChem 2018, 2, 878-883.
Cover picture of Issue 10 of ChemPhotoChem 2018.

Synthesis of α-Aminonitriles using Aliphatic Nitriles, α-Amino Acids, and Hexacyanoferrate as Universally Applicable Non-Toxic Cyanide Sources
A. M. Nauth, T. Konrad, Z. Papadopulu, N. Vierengel, B. Lipp, T. Opatz, Green Chem. 2018, 20, 4217-4223. (Cover picture).

Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice
E. Pflimlin, M. Bielohuby, M. Korn, K. Breitschopf, M. Löhn, P. Wohlfart, A. Konkar, M. Podeschwa, F. Bärenz, A. Pfenninger, U. Schwahn, T. Opatz, M. Reimann, S. Petry, N. Tennagels, Cell Metab. 2018, 28, 217-227.

Prenylated isoflavones from the stem bark of Erythrina sacleuxii
J. O. Ombito, R. R.T. Majinda, I. B. Masesane, G. Bojase, A. Schüffler, Till Opatz, Phytochem Lett. 2018, 26, 110–114.

A Regio- and Diastereoselective Anodic Aryl-Aryl-Coupling in the Biomimetic Total Synthesis of (–)-Thebaine
A. Lipp, D. Ferenc, C. Gütz, M. Geffe, N. Vierengel, D. Schollmeyer, H. J. Schäfer, S. R. Waldvogel, T. Opatz,
Angew. Chem. Int. Ed. 2018, 57, 11055-11059. (VIP manuscript) (Cover picture)
Angew. Chem. 2018, 130, 11221-11225. (VIP-Manuskript) (Titelbild)

Synthesis of Lamellarin G Trimethyl Ether via von Miller-Plöchl-Type Cyclocondensation
V. C. Colligs, C. Dialer, T. Opatz, Eur. J. Org. Chem. 2018, 4064-4070.

Crystal Structure Analysis of a "Star-Shaped" Triazine Compound: A Combination of Single-Crystal Electron Diffraction and Powder X-Ray Diffraction
T. Gorelik, J. van de Streek, H. Meier, L. Andernach, T. Opatz, Acta Crystallogr. B 2018, 287-294.

Visible Light Driven Minisci-Type Reaction with N-Hydroxyphthalimide Esters
L. M. Kammer, A. Rahman, T. Opatz, Molecules 2018, 23, 764.

Visible Light Organophotoredox-catalyzed Synthesis of Horner Precursors
M. M. Nebe, D. Loeper, F. Fürmeyer, T. Opatz, Eur. J. Org. Chem. 2018, 2471-2476.

Recent Advances in the Synthesis of Piperidines: Functionalization of Preexisting Ring Systems
G.-Q. Liu, T. Opatz, Adv. Heterocycl. Chem. 2018, 125, 107–234.

Mechanism and cis/trans Selectivity of Vinylogous Nazarov-Type [6π] Photocyclizations
S. Pusch, A. Tröster, D. Lefrancois, P. Farahani, A. Dreuw, T. Bach, T. Opatz, J. Org. Chem. 2018, 83, 964–972.

Synthesis and Unusual NMR-Spectroscopic Behavior of a Strained Bicyclic Ammonium Salt
S. Pusch, D. Schollmeyer, T. Opatz, Eur. J. Org. Chem. 2018, 1204-1207. (Cover picture)

Identification and Characterization of a Single High-Affinity Fatty Acid Binding Site in Human Serum Albumin
L. Wenskowsky, H. Schreuder, V. Derdau, H. Matter, J. Volkmar, T. Opatz, S. Petry, Angew. Chem. 2018, 57, 1044–1048.

Silver Oxide Mediated Monotosylation of Poly(ethylene glycol): Heterobifunctional PEG via Polymer Desymmetrization
H. Pohlit, M. Worm, J. Langhanki, E. Berger-Nicoletti, T. Opatz, H. Frey, Macromolecules 2017, 50, 9196–9206.

Oxidation of Trialkylamines by BrCCl₃—Scope, Applications and Mechanistic Aspects
A. M. Nauth, J. C. Orejarena Pacheco, S. Pusch, T. Opatz, Eur. J. Org. Chem. 2017, 6966–6974.

Polyethylene bio-degradation by caterpillars?
C. Weber, S. Pusch, T. Opatz, Curr. Biol. 2017, 27, R744-R745.

Phytotoxic dioxolanones are potential virulence factors in the infection process of Guignardia bidwellii
I. Buckel, L. Andernach, A. Schüffler, M. Piepenbring, T. Opatz, E. Thines, Sci. Rep. 2017, 7, 8926.

Examples of Xylochemistry: Colorants and Polymers
J. Kühlborn, A.-K. Danner, H. Frey, R. Iyer, A. J. Arduengo III, T. Opatz, Green Chem. 2017, 19, 3780–3786.

A New Member of the Fusaricidin Family – Structure Elucidation and Synthesis of Fusaricidin E
M. Reimann, L. P. Sandjo, L Antelo, E. Thines, I. Siepe, T. Opatz, Beilstein J. Org. Chem. 2017, 13, 1430–1438.

Modular De Novo Synthesis of Unsymmetrical BODIPY Dyes possessing four different Aryl Substituents
N. Netz, C. Díez-Poza, A. Barbero, T. Opatz, Eur. J. Org. Chem. 2017, 4580–4599.

Cytotoxicity of Secondary Metabolites from Dracaena viridiflora Engl & Krause and their Semisynthetic Analogues
R. B. Teponno, J. P. Dzoyem, R. N. Nono, U. Kauhl, L. P. Sandjo, L. A. Tapondjou, U. Bakowsky, T. Opatz, Rec. Nat. Prod. 2017, 11, 421–430.

Photo-Chromium: Sensitizer for Visible Light-Induced Oxidative C-H Bond Functionalization – Electron or Energy Transfer?
S. Otto, A. M. Nauth, E. Ermilov, N. Scholz, A. Friedrich, U. Resch-Genger, S. Lochbrunner, T. Opatz, K. Heinze, ChemPhotoChem 2017, 1, 344–349.
Cover picture of Issue 8.

The Chinese herbal formula Free and Easy Wanderer ameliorates oxidative stress through the KEAP1-NRF2/HO-1 pathway
C. Hong, J. Cao, C.-F. Wu, O. Kadioglu, A. Schüffler, U. Kauhl, S. M. Klauck, T. Opatz, E. Thines, T. Efferth, Sci. Rep. 2017, 7, 11551.

New Photochemical Approaches to the Bilobalide Core
J. Emsermann, T. Opatz, Eur. J. Org. Chem. 2017, 3362–3372.

Light-Induced Alkylation of (Hetero)aromatic Nitriles in a Transition Metal-Free C–C-Bond Metathesis
B. Lipp, A. Lipp, H. Detert, T. Opatz, Org. Lett. 2017, 19, 2054–2057.

Identification of NF-κB as Determinant of Posttraumatic Stress Disorder and Its Inhibiton by the Chinese Herbal Remedy Free and Easy Wanderer
C. Hong, A. Schüffler, U. Kauhl, J. Cao, C.-F. Wu, T. Opatz, E. Thines, T. Efferth, Front. Pharmacol. 2017, 8, 181.

“Clickable PEG” via anionic copolymerization of ethylene oxide and glycidyl propargyl ether
J. Herzberger, D. Leibig, J. Langhanki, C. Moers, T. Opatz, H. Frey, Polym. Chem. 2017, 8, 1882–1887.

Bioconjugation of small molecules to RNA impedes its recognition by Toll-like receptor 7 (TLR7)
I. Hellmuth, I. Freund, J. Schlöder, S. Seidu-Larry, K. Thüring, K. Slama, J. Langhanki, S. Kaloyanova, T. Eigenbrod, M. Krumb, S. Röhm, K. Peneva, T. Opatz, H. Jonuleit, A. H. Dalpke, M. Helm, Front. Immunol. 2017, 8, 312.

Synthesis and Biological Evaluation of a D-Ring-contracted Analogue of Lamellarin D
V. C. Colligs, S. P. Hansen, D. Imbri, E.-J. Seo, O. Kadioglu, T. Efferth, T. Opatz, Bioorg. Med. Chem. 2017, 6137-6148.

An Asymmetric One-Pot Synthesis of (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol: A Key Component of Current HIV Protease Inhibitors
A. Sevenich, G.-Q. Liu, A. J. Arduengo III, B. F. Gupton, T. Opatz, J. Org. Chem. 2017, 82, 1218–1223.
Article was highlighted in: Synfacts 2017, 13, 0343.

A Modular Access to (+/-)-Tubocurine and (+/-)-Curine - Formal Total Synthesis of Tubocurarine
N. Otto, D. Ferenc, T. Opatz, J. Org. Chem. 2017, 82, 1205–1217.

Sunflow: Sunlight Drives Fast and Green Photochemical Flow Reactions in Simple Micro Capillary Reactors — Application to Photoredox- and H-Atom Transfer Chemistry
A. M. Nauth, A. Lipp, B. Lipp, T. Opatz, Eur. J. Org. Chem. 2017, 2099–2103.
Link to Video Abstract.

Synthesis of Piperidines and Dehydropiperidines: Construction of the Six-Membered Ring
M. M. Nebe, T. Opatz, Adv. Heterocycl. Chem. 2017, 122, 191–244.

Haloperoxidase mimicry by CeO_2-x nanorods combats biofouling
K. Herget. P. Hubach, S. Pusch, P. Deglmann, H. Götz, T. E. Gorelik, I. A. Gural'skiy, F. Pfitzner, T. Link, S. Schenk, M. Panthöfer, V. Ksenofontov, U. Kolb, T. Opatz, R. André, W. Tremel
Adv. Mater. 2017, 29, 1603823.

ESI-MS2 and anti-inflammatory studies of cyclopropanic triterpenes. UPLC-ESI-MS and MS2 search of related metabolites from Donella ubanguiensis
L. P. Sandjo, M. V. P. dos Santos Nascimento, L. A. L. da Silva, A. C. M. Munhoz, L. A. E. Pollo, M. W. Biavatti, B. T. Ngadjui, T. Opatz, T. S. Fröde
Phytochem. Anal. 2017, 28, 27–41.

Unravelling the biosynthesis of pyriculol in the rice blast fungus Magnaporthe oryzae
Stefan Jacob; Thomas Grötsch; Andrew J. Foster; Anja Schüffler; Patrick H. Rieger; Louis P. Sandjo; Johannes C. Liermann; Till Opatz; Eckhard Thines
Microbiology 2017, 163, 541–553.

Characterization of the synthetic cannabinoid MDMB-CHMCZCA
Carina Weber, Stefan Pusch, Dieter Schollmeyer, Sascha Münster-Müller, Michael Pütz and Till Opatz
Beilstein J. Org. Chem. 2016, 12, 2808–2815.

Anti-inflammatory Tetraquinane Diterpenoids from a Crinipellis species
Markus Rohr, Katharina Oleinikov, Mathias Jung, Louis P. Sandjo, Till Opatz, Gerhard Erkel
Bioorg. Med. Chem. 2016, 25, 514–522.

Absolute Configuration Determination of 2,3-Dihydro-1H,5H-pyrazolo-[1,2-a]pyrazoles using Chiroptical Methods at Different Wavelengths.
Eva Pušavec Kirar, Uroš Grošelj, Amalija Golobič, Franc Požgan, Stefan Pusch, Carina Weber, Lars Andernach, Bogdan Štefane, Till Opatz, Jurij Svete
J. Org. Chem. 2016, 81, 11802–11812.

Terphenyl Derivatives from Allantophomopsis lycopodina
Andernach, Lars; Sandjo, Louis; Liermann, Johannes; Schlämann, Ricardo; Richter, Christian; Ferner, Jan-Peter; Schwalbe, Harald; Schueffler, Anja; Thines, Eckhard; Opatz, Till
J. Nat. Prod. 2016, 79, 2718–2725.

Transition Metal-free Decarboxylative Photoredox Coupling of Carboxylic Acids and Alcohols with Aromatic Nitriles
B. Lipp, A. M. Nauth, T. Opatz
J. Org. Chem. 2016, 81, 6875-6882.

A Short and Modular Approach towards 3,5-Disubstituted Indolizidine Alkaloids
M. M. Nebe, S. Zinn, T. Opatz
Org. Biomol. Chem. 2016, 14, 7084-7091.

Total Synthesis of Phenanthroindolizidine Alkaloids by Combining Iodoaminocyclization with a Free Radical Cyclization
G.-Q. Liu, M. Reimann, T. Opatz
J. Org. Chem. 2016, 81, 6142-6148.

Secondary brown carbon formation via the dicarbonyl imine pathway: Nitrogen heterocycle formation and synergistic effects
C. J. Kampf, A. Filippi, C. Zuth, T. Hoffmann, T. Opatz
Phys. Chem. Chem. Phys. 2016, 18, 18353-18364.

A Light-Induced Vinylogous Nazarov-Type Cyclization
S. Pusch, D. Schollmeyer, T. Opatz
Org. Lett. 2016, 18, 3043-3045.

Separation, isolation and stereochemical assignment of imazalil enantiomers and their quantitation in an in vitro toxicity test
M. Escolà Casas, A. C. Kretschmann, L. Andernach, T. Opatz, K. Bester
J. Chromatogr. A 2016, 1452, 116-120.

Light Induced C–C Coupling of 2-Chlorobenzazoles with Carbamates, Alcohols, and Ethers
A. Lipp, G. Lahm, T. Opatz
J. Org. Chem. 2016, 81, 4890-4897.

Absolute configuration of the synthetic cannabinoid MDMB-CHMICA with its chemical characteristics in illegal products
L. Andernach, S. Pusch, C. Weber, D. Schollmeyer, S. Münster-Müller, M. Pütz, T. Opatz, Forensic Toxicol. 2016, 34, 344-352.

3,4-Dihydro-2H-pyrrole-2-carbonitriles – Useful Intermediates in the Synthesis of Fused Pyrroles
and 2,2’-Bipyrroles
M. M. Nebe, M. Kücükdisli, T. Opatz
J. Org. Chem 2016, 81, 4112-4121.

A Photoinduced Cobalt-Catalyzed Synthesis of Pyrroles through In-Situ Generated Acylazirines
S. Pusch, D. Kowalczyk, T. Opatz, J. Org. Chem. 2016, 81, 4170-4178.

A Surprising Switch in Absolute Configuration of Anti-Inflammatory Macrolactones
J. Tauber, M. Rohr, T. Walter, D. Schollmeyer, K. Rahn-Hotze, G. Erkel, T. Opatz
Org. Biomol. Chem. 2016, 14, 3695-3698.

A Short Synthesis of Pyridines from Deprotonated α-Aminonitriles by an Alkylation/RCM Sequence
C. Weber, M. M. Nebe, L. P. V. Kaluza, T. Opatz
Z. Naturforsch. B 2016, 71, 633-641.

Antifungal Paenibacillus Strains, Fusaricidin-Type Compounds, and their Use.
I. Siepe, H. Brüser, K. Klappach, K.-H. Schneider, P. Spröte, K. Hage, B. Blanz, E. Thines, L. Antelo, L. P. Sandjo, T. Opatz
PCT Int. Appl. 2016, WO2016020371.

Synthesis of 1,2-Disubstituted Indoles from α-Aminonitriles and 2-Halobenzyl Halides
A.-K. Bachon, T. Opatz
J. Org. Chem. 2016, 81, 1858-1869.

A Modular Formal Total Synthesis of (±)-Cycloclavine
N. Netz, T. Opatz
J. Org. Chem 2016, 81, 1723-1730.

A Highly Active System for the Metal-Free Aerobic Photocyanation of Tertiary Amines with Visible Light: Application to the Synthesis of Tetraponerines and Crispine A
J. C. Orejarena Pacheco, A. Lipp, A. M. Nauth, F. Acke, J.-P. Dietz, T. Opatz
Chem. Eur. J. 2016, 22, 5409-5415.

Marine Isonitriles and Their Related Compounds
J. Emsermann, U. Kauhl, T. Opatz
Marine Drugs 2016, 14, 16.

A Short Synthesis of 2,3,5-Trisubstituted Pyrroles by an Alkylation/Dehydrocyanation Sequence
M. Kücükdisli, M. M. Nebe, S. M. Bartelt, T. Opatz
Heterocycles 2016, 93, 378–390.

Total Synthesis of (–)-Hymenosetin
U. Kauhl, L. Andernach, S. Weck, L. Sandjo, S. Jacob, E. Thines, T. Opatz
J. Org. Chem. 2016, 81, 215-228.
Synfacts 2016, 12, 224.

Total Synthesis of (±)-Scopolamine: Challenges of the Tropane Ring
P.-A. Nocquet, T. Opatz
Eur. J. Org. Chem. 2016, 1156-1164.